Abstract :The phrase in silico coined in 1989 means “performed on computer or via computer simulation”. It is an illusion of the Latin phrases in vivo, in vitro and in situ used in biology to express experiments done in living organisms, outside of living organisms, and where they are found in nature, respectively. Similarly the term “in silico pharmacology or computational therapeutics or computational pharmacology” explains various computational approaches available for modeling of biological processes such as biochemical, biophysical and immunological leading to therapeutic advancements. Computational approaches along with mathematical methods help to characterize the pharmacology of substances within the living organisms. in silico pharmacology is a growing area covering the use of software to capture, analyze and integrate biological and medical data available from different sources.